AOD9604 Spray
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AOD9604 Spray by BeaCapra — premium research-grade compound verified to ≥99.0% purity via independent HPLC and LC-MS analysis.
Supplied as a pre-dissolved metered nasal spray solution in a 30ml amber glass atomizer with precision dosing mechanism. Each actuation delivers a consistent, measured dose for reliable experimental protocols.
Specifications
- Purity: ≥99.0% (HPLC verified)
- Form: Pre-Dissolved Metered Spray (30ml)
- Category: Metabolic Research
- Storage: -20°C recommended, protect from light
Quality Assurance
Every BeaCapra product ships with a Certificate of Analysis (COA) documenting purity verification via HPLC and mass spectrometry. Our compounds are synthesized under strict GMP-adjacent protocols and undergo batch-level quality control.
For Research Use Only (RUO). Not intended for human consumption, therapeutic, or diagnostic use.
Research Benefits
- Lipolytic Activity Without IGF-1 — AOD-9604 is a modified fragment (amino acids 176-191) of human growth hormone that retains fat-metabolizing properties without stimulating IGF-1 production or inducing growth effects.
- Fat Metabolism Research — Studies show AOD-9604 stimulates lipolysis and inhibits lipogenesis in adipocyte models, making it a focused tool for fat biology research.
- Cartilage Repair Studies — Emerging research has explored AOD-9604's chondrogenic properties, with studies suggesting it stimulates proteoglycan synthesis in cartilage explant models.
- Metabolic Safety Profile — Unlike full-length hGH, AOD-9604 does not affect blood glucose, insulin sensitivity, or IGF-1 levels in published preclinical studies.
Mechanism of Action
AOD-9604 (Anti-Obesity Drug 9604) is a synthetic 16-amino acid peptide corresponding to the C-terminal fragment (residues 176-191) of human growth hormone, with a tyrosine residue added at the N-terminus.
Lipolytic Pathway: AOD-9604 activates the β3-adrenergic receptor signaling cascade in adipose tissue, stimulating hormone-sensitive lipase (HSL) and promoting triglyceride hydrolysis without requiring full GH receptor activation.
Anti-Lipogenic: AOD-9604 inhibits fatty acid synthase (FAS) and other lipogenic enzymes, reducing de novo lipogenesis in adipocyte models.
No IGF-1 Stimulation: Unlike full-length hGH, the 176-191 fragment does not activate the GH receptor dimerization required for JAK2/STAT5 signaling and IGF-1 gene transcription, decoupling fat metabolism from growth-promoting effects.
Chondrocyte Effects: AOD-9604 has been shown to stimulate proteoglycan and type II collagen synthesis in chondrocytes through pathways that may involve SOX9 transcription factor upregulation.
Research Protocol
For research use only.
Reconstitution
Reconstitute in bacteriostatic water. Stock: 1-2 mg/mL.
Research Dosing (from published studies)
- In vivo (murine, lipolysis): 500 mcg/kg SC daily for 14-28 days.
- In vitro (adipocytes): 1-50 μg/mL for lipolysis and lipogenesis assays.
- Cartilage models: 100-500 nM in chondrocyte pellet cultures for 14-21 days.
Storage
Lyophilized at -20°C. Reconstituted at 2-8°C, use within 21 days.
Safety & Handling
Research Use Only.
Storage Conditions
- Lyophilized: -20°C
- Reconstituted: 2-8°C, 21 days
Known Considerations from Literature
- AOD-9604 does not affect glucose homeostasis or insulin sensitivity at published research doses.
- No significant IGF-1 elevation, diabetogenic effects, or growth promotion reported.
- Generally well-tolerated in published preclinical and phase 2 studies.
Frequently Asked Questions
- What is AOD-9604?
- AOD-9604 is a synthetic peptide fragment (amino acids 176-191) of human growth hormone, designed to retain the lipolytic properties of hGH without its growth-promoting or diabetogenic effects.
- Does AOD-9604 increase IGF-1?
- No. AOD-9604 does not activate the GH receptor signaling cascade (JAK2/STAT5) required for IGF-1 gene transcription. This is a key advantage for studying fat metabolism independent of growth factor effects.
- What purity is this product?
- BeaCapra AOD-9604 is ≥99% pure by HPLC with COA provided.
- How does AOD-9604 relate to cartilage research?
- Beyond fat metabolism, AOD-9604 has shown chondroprotective properties in published studies, stimulating proteoglycan and collagen synthesis in cartilage models. This dual application makes it of interest in both metabolic and musculoskeletal research.
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Customer Reviews
Exceptional purity and fast shipping
Third-party COA verified at 99.1% purity. Arrived in 2 days with proper cold packaging. The documentation included was thorough and professional. Will be ordering again for our lab.
Best supplier I've found
After trying several suppliers, BeaCapra consistently delivers the highest quality compounds. The subscribe & save option is a great value, and their customer support team answered all my questions promptly.
Great product, COA checks out
Ran our own HPLC analysis and confirmed the purity claims. Packaging was secure and discreet. Only minor note — would love to see more size options for some of the newer compounds. Otherwise excellent.
Subscribe & save is the way to go
The 15% discount on subscription makes this the most competitive pricing I've found for research-grade compounds at this purity level. Auto-delivery every 30 days has been seamless. Highly recommend.
Exactly what our research team needed
We've been sourcing from BeaCapra for our university lab and the consistency batch-to-batch is impressive. Every order comes with a COA and the compounds are properly lyophilized. Professional operation all around.
Questions About AOD9604 Spray
General Questions
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