ARA-290 Spray
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ARA-290 Spray by BeaCapra — premium research-grade compound verified to ≥99.0% purity via independent HPLC and LC-MS analysis.
Supplied as a pre-dissolved metered nasal spray solution in a 30ml amber glass atomizer with precision dosing mechanism. Each actuation delivers a consistent, measured dose for reliable experimental protocols.
Specifications
- Purity: ≥99.0% (HPLC verified)
- Form: Pre-Dissolved Metered Spray (30ml)
- Category: Recovery Research
- Storage: -20°C recommended, protect from light
Quality Assurance
Every BeaCapra product ships with a Certificate of Analysis (COA) documenting purity verification via HPLC and mass spectrometry. Our compounds are synthesized under strict GMP-adjacent protocols and undergo batch-level quality control.
For Research Use Only (RUO). Not intended for human consumption, therapeutic, or diagnostic use.
Research Benefits
- Innate Repair Receptor Activation — ARA-290 (Cibinetide) activates the innate repair receptor (IRR), a heterocomplex of EPOR and CD131 (βc), distinct from the classical erythropoietin receptor.
- Neuroprotection — ARA-290 demonstrates neuroprotective effects in small fiber neuropathy and diabetic neuropathy models without erythropoietic stimulation.
- Tissue Repair — IRR activation promotes tissue repair through anti-apoptotic, anti-inflammatory, and pro-angiogenic mechanisms without affecting red blood cell production.
- Sarcoidosis Research — Published clinical studies have examined ARA-290 in sarcoidosis-associated small fiber neuropathy, a condition with limited treatment options.
Mechanism of Action
ARA-290 is a synthetic 11-amino acid peptide derived from the B-helix of erythropoietin. It selectively activates the innate repair receptor (IRR) without activating the classical erythropoietin receptor (EPOR/EPOR homodimer).
IRR Activation: The IRR is a heterocomplex of EPOR and CD131 (β common chain). ARA-290 binds this heterocomplex with nanomolar affinity, triggering JAK2/STAT3 signaling in a tissue-protective rather than erythropoietic context.
Anti-Apoptotic: IRR activation upregulates anti-apoptotic proteins (Bcl-2, Bcl-xL) and inhibits caspase-3 activation in neurons, cardiomyocytes, and endothelial cells under stress conditions.
Anti-Inflammatory: ARA-290 suppresses NF-κB-dependent pro-inflammatory cytokine production and macrophage activation through IRR-mediated signaling.
No Erythropoiesis: ARA-290 does not activate the EPOR/EPOR homodimer on erythroid progenitors, so it has no effect on red blood cell production, hematocrit, or blood viscosity.
Research Protocol
For research use only.
Reconstitution
Reconstitute in sterile saline or PBS. Stock: 1 mg/mL.
Research Dosing (from published studies)
- In vivo (murine, neuropathy): 10-30 μg/kg SC or IV daily for 14-28 days.
- In vitro: 1-100 ng/mL for neuroprotection and anti-inflammatory assays.
- Published clinical reference: 2-8 mg SC daily or three times weekly.
Storage
Lyophilized at -20°C. Reconstituted at 2-8°C, use within 14 days.
Safety & Handling
Research Use Only.
Known Considerations
- ARA-290 does not stimulate erythropoiesis and has no effect on hematocrit or blood viscosity.
- No significant adverse effects reported in published clinical studies at standard doses.
- Short plasma half-life (~2-5 minutes) may limit systemic exposure in acute dosing designs.
Frequently Asked Questions
- What is ARA-290?
- ARA-290 (Cibinetide) is a synthetic peptide derived from erythropoietin's B-helix that selectively activates the innate repair receptor (IRR) for tissue protection without stimulating red blood cell production.
- How is ARA-290 different from EPO?
- EPO activates both the classical EPOR homodimer (erythropoiesis) and the IRR (tissue protection). ARA-290 activates only the IRR, providing tissue-protective effects without erythropoietic stimulation or thrombotic risk.
- What purity is this product?
- BeaCapra ARA-290 is ≥99% pure by HPLC with COA provided.
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Customer Reviews
Exceptional purity and fast shipping
Third-party COA verified at 99.1% purity. Arrived in 2 days with proper cold packaging. The documentation included was thorough and professional. Will be ordering again for our lab.
Best supplier I've found
After trying several suppliers, BeaCapra consistently delivers the highest quality compounds. The subscribe & save option is a great value, and their customer support team answered all my questions promptly.
Great product, COA checks out
Ran our own HPLC analysis and confirmed the purity claims. Packaging was secure and discreet. Only minor note — would love to see more size options for some of the newer compounds. Otherwise excellent.
Subscribe & save is the way to go
The 15% discount on subscription makes this the most competitive pricing I've found for research-grade compounds at this purity level. Auto-delivery every 30 days has been seamless. Highly recommend.
Exactly what our research team needed
We've been sourcing from BeaCapra for our university lab and the consistency batch-to-batch is impressive. Every order comes with a COA and the compounds are properly lyophilized. Professional operation all around.
Questions About ARA-290 Spray
General Questions
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