Dulaglutide
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Dulaglutide by BeaCapra — premium research-grade compound verified to ≥99.0% purity via independent HPLC and LC-MS analysis.
Supplied as lyophilized (freeze-dried) powder in vacuum-sealed glass vials. Each batch undergoes rigorous third-party testing to ensure pharmaceutical-grade consistency and stability.
Specifications
- Purity: ≥99.0% (HPLC verified)
- Form: Lyophilized Powder
- Category: Metabolic Research
- Storage: -20°C recommended, protect from light
Quality Assurance
Every BeaCapra product ships with a Certificate of Analysis (COA) documenting purity verification via HPLC and mass spectrometry. Our compounds are synthesized under strict GMP-adjacent protocols and undergo batch-level quality control.
For Research Use Only (RUO). Not intended for human consumption, therapeutic, or diagnostic use.
Research Benefits
- Long-Acting GLP-1 Research — Dulaglutide is an Fc-fused GLP-1 receptor agonist with a long half-life, enabling once-weekly dosing in research protocols.
- Cardiovascular Outcomes — Published studies (REWIND trial) examined dulaglutide's cardiovascular effects, establishing it as a reference compound for GLP-1R agonist cardiovascular research.
- Beta-Cell Biology — GLP-1R agonism enhances glucose-dependent insulin secretion and promotes β-cell proliferation in preclinical models, supporting islet biology research.
- Neuroprotection — Emerging research explores GLP-1R agonists including dulaglutide for neuroprotective properties in neurodegeneration models.
Mechanism of Action
Dulaglutide is a GLP-1 receptor agonist consisting of a modified GLP-1 analog covalently linked to a human IgG4-Fc domain via a small peptide linker.
GLP-1R Activation: Binds and activates the GLP-1 receptor on pancreatic β-cells, stimulating Gs-coupled adenylyl cyclase, increasing cAMP, and activating PKA and Epac2. This enhances glucose-dependent insulin exocytosis.
Glucagon Suppression: GLP-1R activation on pancreatic α-cells suppresses glucagon secretion in a glucose-dependent manner, reducing hepatic glucose output.
Central Satiety: GLP-1R activation in the hypothalamus (arcuate nucleus) and brainstem (NTS) promotes satiety and reduces food intake.
Fc Fusion Technology: The IgG4-Fc domain prevents FcRn-mediated degradation and extends plasma half-life to ~5 days, enabling weekly dosing. The IgG4 isotype minimizes immune effector functions (ADCC, CDC).
Research Protocol
For research use only.
Reconstitution
Reconstitute in bacteriostatic water or PBS. Stock: 1 mg/mL.
Research Dosing (from published studies)
- In vivo (murine): 0.6-3 mg/kg SC once weekly for metabolic studies.
- Published clinical reference: 0.75-1.5 mg SC once weekly.
- In vitro: 1-100 nM for β-cell proliferation and insulin secretion assays.
Storage
Lyophilized at -20°C. Reconstituted at 2-8°C, use within 14 days.
Safety & Handling
Research Use Only.
Known Considerations from Literature
- GI adverse events (nausea, diarrhea, vomiting) are dose-dependent and typically transient.
- GLP-1R agonists have been associated with pancreatitis signals in post-marketing data; monitor amylase/lipase in chronic studies.
- Anti-drug antibody formation possible due to the protein/Fc component.
- Injection site reactions may occur.
Frequently Asked Questions
- What is Dulaglutide?
- Dulaglutide is a GLP-1 receptor agonist engineered by fusing a modified GLP-1 peptide to a human IgG4-Fc domain. The Fc fusion extends its half-life for once-weekly administration in research.
- How does Fc fusion extend half-life?
- The IgG4-Fc domain binds the neonatal Fc receptor (FcRn) in endosomes, recycling the molecule back to the plasma instead of being degraded. This extends the half-life from ~2 minutes (native GLP-1) to ~5 days.
- What purity is this product?
- BeaCapra Dulaglutide is ≥99% pure with COA documentation provided.
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Customer Reviews
Exceptional purity and fast shipping
Third-party COA verified at 99.1% purity. Arrived in 2 days with proper cold packaging. The documentation included was thorough and professional. Will be ordering again for our lab.
Best supplier I've found
After trying several suppliers, BeaCapra consistently delivers the highest quality compounds. The subscribe & save option is a great value, and their customer support team answered all my questions promptly.
Great product, COA checks out
Ran our own HPLC analysis and confirmed the purity claims. Packaging was secure and discreet. Only minor note — would love to see more size options for some of the newer compounds. Otherwise excellent.
Subscribe & save is the way to go
The 15% discount on subscription makes this the most competitive pricing I've found for research-grade compounds at this purity level. Auto-delivery every 30 days has been seamless. Highly recommend.
Exactly what our research team needed
We've been sourcing from BeaCapra for our university lab and the consistency batch-to-batch is impressive. Every order comes with a COA and the compounds are properly lyophilized. Professional operation all around.
Questions About Dulaglutide
General Questions
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