Epithalon
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Epithalon by BeaCapra — premium research-grade compound verified to ≥99.0% purity via independent HPLC and LC-MS analysis.
Supplied as lyophilized (freeze-dried) powder in vacuum-sealed glass vials. Each batch undergoes rigorous third-party testing to ensure pharmaceutical-grade consistency and stability.
Specifications
- Purity: ≥99.0% (HPLC verified)
- Form: Lyophilized Powder
- Category: Metabolic Research
- Storage: -20°C recommended, protect from light
Quality Assurance
Every BeaCapra product ships with a Certificate of Analysis (COA) documenting purity verification via HPLC and mass spectrometry. Our compounds are synthesized under strict GMP-adjacent protocols and undergo batch-level quality control.
For Research Use Only (RUO). Not intended for human consumption, therapeutic, or diagnostic use.
Research-Documented Benefits
- Telomerase Activation — Epithalon (Ala-Glu-Asp-Gly) has demonstrated activation of telomerase in human somatic cells, potentially counteracting telomere shortening associated with cellular aging.
- Circadian Rhythm Regulation — Research shows normalization of melatonin production via pineal gland stimulation, supporting healthy sleep-wake cycles in aged subjects.
- Antioxidant Enhancement — Studies indicate upregulation of endogenous antioxidant enzyme activity, including superoxide dismutase and glutathione peroxidase.
- Lifespan Extension — Preclinical studies by Khavinson et al. demonstrated increased mean lifespan in Drosophila and rodent models with chronic epithalon administration.
- Neuroendocrine Modulation — Documented restoration of age-related decline in reproductive function and gonadotropin cycling in aged animal models.
Mechanism of Action
Epithalon (Ala-Glu-Asp-Gly) is a synthetic tetrapeptide based on the natural pineal gland peptide epithalamin, developed by Professor Vladimir Khavinson at the St. Petersburg Institute of Bioregulation and Gerontology.
Primary Pathways
- Telomerase Activation — Epithalon induces expression of the catalytic subunit of telomerase (hTERT) in human somatic cells, enabling elongation of telomeric DNA sequences that shorten with each cell division.
- Pineal Gland Stimulation — Stimulates melatonin synthesis and secretion from the pineal gland, restoring circadian rhythmicity that declines with aging due to pineal calcification.
- Antioxidant Gene Expression — Upregulates expression of endogenous antioxidant enzymes including superoxide dismutase (SOD), catalase, and glutathione peroxidase.
- Neuroendocrine Regulation — Modulates hypothalamic-pituitary axis activity, influencing gonadotropin release patterns and reproductive function in aged organisms.
Epithalon's mechanism centers on restoring cellular replicative potential via telomere maintenance, while simultaneously normalizing neuroendocrine function associated with aging.
Research Protocol Guidelines
All protocols described are for in vitro and in vivo research purposes only. Not for human use.
Reconstitution
Reconstitute lyophilized Epithalon with bacteriostatic water. For a 10 mg vial, adding 2 mL yields 5 mg/mL. Epithalon dissolves readily due to its small tetrapeptide size.
Research Dosing (Preclinical Literature)
- Khavinson protocol: 5-10 mg/day subcutaneously for 10-20 day cycles, repeated 2-3 times per year in rodent longevity studies
- In vitro telomerase studies: 10-100 nM concentrations in cell culture media for fibroblast and endothelial cell assays
- Cyclical administration: 10-day treatment cycles with 4-6 month intervals between cycles in long-term animal studies
Storage
Store lyophilized form at -20°C for up to 36 months. Reconstituted solution at 2-8°C, use within 21 days. Tetrapeptide stability is generally excellent due to the small molecular size.
Safety & Handling Information
For research use only. Not intended for human or veterinary diagnostic or therapeutic use.
Storage Requirements
- Lyophilized: -20°C, desiccated, light-protected
- Reconstituted: 2-8°C, use within 21 days
Preclinical Safety Profile
Epithalon has been studied over 35+ years by Khavinson's group with no reported significant adverse effects. Chronic administration in rodent longevity studies (lifetime duration) showed no increase in tumor incidence despite telomerase activation.
Known Considerations
- Telomerase activation is a hallmark of most human cancers; however, epithalon studies show tissue-specific activation in somatic cells without transformation, potentially due to co-activation of tumor suppressor pathways
- Melatonin modulation may affect circadian-sensitive experimental designs
- Reproductive endocrine effects in aged animals should be considered in breeding-related studies
Handling
Standard laboratory PPE. Epithalon's small size (tetrapeptide) makes it unlikely to cause immune sensitization. Dispose according to institutional guidelines.
Frequently Asked Questions
What is Epithalon and who developed it?
Epithalon (also spelled Epitalon) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) developed by Professor Vladimir Khavinson at the St. Petersburg Institute of Bioregulation and Gerontology. It is based on the natural pineal gland extract epithalamin, which Khavinson's group studied beginning in the 1980s.
How does telomerase activation work?
Epithalon stimulates expression of hTERT, the catalytic subunit of telomerase, in somatic cells. Telomerase adds TTAGGG hexanucleotide repeats to chromosome ends, counteracting the progressive telomere shortening that limits cell division potential (the Hayflick limit).
Is cyclical administration necessary?
Published research by Khavinson's group uses 10-20 day treatment cycles repeated 2-3 times per year. This cyclical approach is designed to mirror natural bioregulator peptide signaling patterns and has been the standard protocol across decades of published studies.
Does telomerase activation increase cancer risk?
While telomerase activation is a hallmark of cancer cells, long-term epithalon studies in rodents showed no increase in spontaneous tumor incidence. Khavinson's group hypothesizes that epithalon activates telomerase in normal somatic cells alongside tumor suppressor mechanisms, distinguishing it from oncogenic telomerase reactivation.
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Customer Reviews
Exceptional purity and fast shipping
Third-party COA verified at 99.1% purity. Arrived in 2 days with proper cold packaging. The documentation included was thorough and professional. Will be ordering again for our lab.
Best supplier I've found
After trying several suppliers, BeaCapra consistently delivers the highest quality compounds. The subscribe & save option is a great value, and their customer support team answered all my questions promptly.
Great product, COA checks out
Ran our own HPLC analysis and confirmed the purity claims. Packaging was secure and discreet. Only minor note — would love to see more size options for some of the newer compounds. Otherwise excellent.
Subscribe & save is the way to go
The 15% discount on subscription makes this the most competitive pricing I've found for research-grade compounds at this purity level. Auto-delivery every 30 days has been seamless. Highly recommend.
Exactly what our research team needed
We've been sourcing from BeaCapra for our university lab and the consistency batch-to-batch is impressive. Every order comes with a COA and the compounds are properly lyophilized. Professional operation all around.
Questions About Epithalon
General Questions
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