BeaCapra GHRP-6 — Growth Drive
Frequently Bought Together
GHRP-6: Potent Growth Hormone Releasing Hexapeptide
GHRP-6 (Growth Hormone Releasing Peptide-6) is a synthetic hexapeptide (His-D-Trp-Ala-Trp-D-Phe-Lys-NH2) that stimulates growth hormone secretion through ghrelin receptor (GHS-R1a) activation. With a molecular weight of 873.01 g/mol, GHRP-6 was among the first synthetic GH secretagogues developed and remains one of the most potent in its class. Each vial contains 5mg of lyophilized peptide at ≥99% purity.
GHRP-6 produces robust, dose-dependent growth hormone release through mechanisms distinct from GHRH. In addition to direct pituitary stimulation, GHRP-6 amplifies GH release by suppressing somatostatin (the endogenous GH-inhibiting hormone) at the hypothalamic level. This dual mechanism produces GH release amplitudes that exceed those of most other secretagogues.
Research also demonstrates that GHRP-6 stimulates appetite through ghrelin pathway activation, increases gastric motility, and has cardioprotective properties in ischemia-reperfusion models. These pleiotropic effects make GHRP-6 a versatile research tool beyond pure GH axis studies.
Storage: Store lyophilized peptide at -20°C. Reconstitute with bacteriostatic water and store at 2-8°C. Use within 30 days. Protect from light.
For research use only. Not for human consumption. This product is not a drug, supplement, food, or cosmetic and may not be misbranded, misused, or mislabeled as such.
Research-Documented Benefits
- Potent GH Secretion — GHRP-6 is one of the strongest growth hormone releasing peptides, producing robust, dose-dependent GH pulses via ghrelin receptor activation.
- Appetite Stimulation — As a ghrelin mimetic, GHRP-6 stimulates appetite through hypothalamic signaling, which may support research in cachexia and wasting conditions.
- Cytoprotective Effects — Research demonstrates cardioprotective and hepatoprotective properties, with reduced ischemia-reperfusion injury in animal models.
- IGF-1 Increase — Sustained administration elevates IGF-1 levels, supporting downstream anabolic and tissue repair pathways.
- Anti-Fibrotic Properties — Studies indicate reduced fibrosis in liver and cardiac tissue models, suggesting anti-scarring potential.
Mechanism of Action
GHRP-6 (His-D-Trp-Ala-Trp-D-Phe-Lys-NH2) is a hexapeptide that mimics the endogenous hormone ghrelin, activating the growth hormone secretagogue receptor type 1a (GHS-R1a).
Primary Pathways
- Ghrelin Receptor Activation — GHRP-6 binds GHS-R1a with high affinity, triggering intracellular calcium mobilization and protein kinase C activation in pituitary somatotrophs.
- Dual GH Release — Promotes GH secretion through both direct pituitary stimulation and hypothalamic GHRH release, while simultaneously suppressing somatostatin, producing robust GH pulses.
- Appetite Stimulation — Activates hypothalamic NPY/AgRP neurons via GHS-R1a, mimicking ghrelin's orexigenic signaling and increasing food intake.
- Cytoprotective Signaling — Activates PI3K/Akt survival pathways in cardiac and hepatic cells, providing protection against ischemia-reperfusion injury.
GHRP-6's broad receptor activation—including appetite stimulation and cortisol release alongside potent GH secretion—distinguishes it from more selective secretagogues like ipamorelin.
Research Protocol Guidelines
All protocols described are for in vitro and in vivo research purposes only. Not for human use.
Reconstitution
Reconstitute lyophilized GHRP-6 with bacteriostatic water. For a 5 mg vial, adding 2.5 mL yields 2 mg/mL.
Research Dosing (Preclinical Literature)
- GH stimulation: 1-2 mcg/kg subcutaneously or intravenously in rodent GH-axis studies
- Appetite studies: 100-300 mcg/kg IP in feeding behavior research models
- Cardioprotection: 100 mcg/kg IP prior to induced ischemia in cardiac research models
- Timing: Administered on an empty stomach in metabolic studies; appetite stimulation onset within 20-30 minutes
Storage
Store lyophilized form at -20°C. Reconstituted at 2-8°C, use within 21 days. GHRP-6 is stable in lyophilized form for up to 24 months at proper storage temperature.
Safety & Handling Information
For research use only. Not intended for human or veterinary diagnostic or therapeutic use.
Storage Requirements
- Lyophilized: -20°C, desiccated
- Reconstituted: 2-8°C, use within 21 days
Preclinical Safety Profile
GHRP-6 has been extensively studied since its synthesis in the 1980s. It is well-tolerated in preclinical models, though its broad receptor activation produces more side effects than selective secretagogues.
Known Considerations
- Appetite stimulation (ghrelin-mimetic effect) may confound metabolic or feeding behavior studies
- Transient cortisol and prolactin elevations at higher doses may affect endocrine-focused research
- Gastric acid secretion increase may be relevant in GI research models
- Standard GH/IGF-1 axis neoplasia considerations apply
Handling
Standard laboratory PPE. GHRP-6 is chemically stable and straightforward to handle under standard peptide protocols.
Frequently Asked Questions
How does GHRP-6 differ from ipamorelin?
Both are GH secretagogues acting at the ghrelin receptor, but GHRP-6 is less selective. It stimulates cortisol, prolactin, and appetite alongside GH release. Ipamorelin, by contrast, provides GH stimulation with minimal effects on other hormones. GHRP-6 produces stronger peak GH pulses but with more off-target effects.
Why does GHRP-6 increase appetite?
GHRP-6 mimics ghrelin's orexigenic signaling at the hypothalamic level, activating neuropeptide Y (NPY) and agouti-related peptide (AgRP) neurons in the arcuate nucleus. This is the same appetite-stimulating pathway activated by endogenous ghrelin before meals.
What cytoprotective applications has GHRP-6 been studied for?
GHRP-6 activates PI3K/Akt survival signaling independent of GH release. Published studies demonstrate protection against cardiac ischemia-reperfusion injury, hepatic fibrosis, and doxorubicin-induced cardiotoxicity in rodent models.
Should GHRP-6 be administered on an empty stomach?
In metabolic research protocols, GHRP-6 is typically administered in a fasted state to maximize GH response. Elevated blood glucose and free fatty acids blunt GH secretagogue-induced GH release via somatostatin-mediated negative feedback.
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Third-party COA verified at 99.1% purity. Arrived in 2 days with proper cold packaging. The documentation included was thorough and professional. Will be ordering again for our lab.
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We've been sourcing from BeaCapra for our university lab and the consistency batch-to-batch is impressive. Every order comes with a COA and the compounds are properly lyophilized. Professional operation all around.
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