H-Frag
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H-Frag by BeaCapra — premium research-grade compound verified to ≥99.0% purity via independent HPLC and LC-MS analysis.
Supplied as lyophilized (freeze-dried) powder in vacuum-sealed glass vials. Each batch undergoes rigorous third-party testing to ensure pharmaceutical-grade consistency and stability.
Specifications
- Purity: ≥99.0% (HPLC verified)
- Form: Lyophilized Powder
- Category: Metabolic Research
- Storage: -20°C recommended, protect from light
Quality Assurance
Every BeaCapra product ships with a Certificate of Analysis (COA) documenting purity verification via HPLC and mass spectrometry. Our compounds are synthesized under strict GMP-adjacent protocols and undergo batch-level quality control.
For Research Use Only (RUO). Not intended for human consumption, therapeutic, or diagnostic use.
Research Benefits
- Targeted Lipolysis: HGH Fragment (176-191) mimics the fat-metabolizing region of growth hormone without full GH effects
- Fat Metabolism Without GH Side Effects: Does not affect blood glucose, insulin levels, or promote cellular proliferation like full-length GH
- Adipocyte-Specific Action: Research demonstrates preferential activity on adipose tissue with minimal effects on other tissues
- Energy Expenditure: Investigated for enhancement of fatty acid oxidation and metabolic rate
Mechanism of Action
HGH Fragment 176-191 is a modified C-terminal fragment of human growth hormone corresponding to amino acids 176-191. Unlike full-length GH, this fragment retains only the lipolytic (fat-burning) activity.
- Beta-3 Adrenergic Mimicry: Activates lipolytic pathways in adipocytes similar to beta-3 adrenergic receptor stimulation
- Hormone-Sensitive Lipase: Stimulates HSL activity for triglyceride hydrolysis in fat cells
- No IGF-1 Stimulation: Does not activate the GH receptor's JAK-STAT pathway responsible for IGF-1 production, avoiding anabolic and proliferative effects
- Anti-Lipogenic: Inhibits lipogenesis (new fat formation) in addition to promoting lipolysis
Research Protocol
For research purposes only. Not for human consumption.
- Typical Research Dose: 250-500 mcg per administration in published studies
- Administration: Subcutaneous injection, ideally into abdominal adipose tissue
- Timing: Fasting state or pre-exercise for optimal lipolytic response
- Research Cycle: 8-12 weeks in body composition studies
- Frequency: 1-2 times daily in most protocols
Reconstitution
- Reconstitute with bacteriostatic water; gently swirl
- Refrigerate at 2-8 °C; use within 30 days
Safety & Storage
- Lyophilized: -20 °C long-term; 2-8 °C up to 6 months
- Reconstituted: 2-8 °C; use within 30 days
- Protect from light
Research Considerations
- Does not affect blood glucose or insulin sensitivity, unlike full-length GH
- No hyperglycemic effects reported in published research
- Carbohydrate intake may blunt lipolytic response
- For research use only
Frequently Asked Questions
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How is HGH Fragment different from full growth hormone?
HGH Fragment 176-191 is a small portion of the GH molecule that retains only the fat-metabolizing activity without affecting blood sugar, insulin, cell proliferation, or IGF-1 levels. It provides the lipolytic benefits without the broader hormonal effects.
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Why is fasting state important?
Elevated insulin levels from carbohydrate intake inhibit hormone-sensitive lipase, the enzyme through which HGH Fragment exerts its lipolytic effect. Fasting or low-insulin states maximize the compound's activity.
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Does this affect IGF-1 levels?
No. HGH Fragment 176-191 does not activate the GH receptor in a way that stimulates hepatic IGF-1 production. IGF-1 levels remain unaffected.
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What purity?
≥99% purity by HPLC/MS. COA available.
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Customer Reviews
Exceptional purity and fast shipping
Third-party COA verified at 99.1% purity. Arrived in 2 days with proper cold packaging. The documentation included was thorough and professional. Will be ordering again for our lab.
Best supplier I've found
After trying several suppliers, BeaCapra consistently delivers the highest quality compounds. The subscribe & save option is a great value, and their customer support team answered all my questions promptly.
Great product, COA checks out
Ran our own HPLC analysis and confirmed the purity claims. Packaging was secure and discreet. Only minor note — would love to see more size options for some of the newer compounds. Otherwise excellent.
Subscribe & save is the way to go
The 15% discount on subscription makes this the most competitive pricing I've found for research-grade compounds at this purity level. Auto-delivery every 30 days has been seamless. Highly recommend.
Exactly what our research team needed
We've been sourcing from BeaCapra for our university lab and the consistency batch-to-batch is impressive. Every order comes with a COA and the compounds are properly lyophilized. Professional operation all around.
Questions About H-Frag
General Questions
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