MT-2 Melanotan II
Frequently Bought Together
MT-2 Melanotan II by BeaCapra — premium research-grade compound verified to ≥99.0% purity via independent HPLC and LC-MS analysis.
Supplied as lyophilized (freeze-dried) powder in vacuum-sealed glass vials. Each batch undergoes rigorous third-party testing to ensure pharmaceutical-grade consistency and stability.
Specifications
- Purity: ≥99.0% (HPLC verified)
- Form: Lyophilized Powder
- Category: Metabolic Research
- Storage: -20°C recommended, protect from light
Quality Assurance
Every BeaCapra product ships with a Certificate of Analysis (COA) documenting purity verification via HPLC and mass spectrometry. Our compounds are synthesized under strict GMP-adjacent protocols and undergo batch-level quality control.
For Research Use Only (RUO). Not intended for human consumption, therapeutic, or diagnostic use.
Research Benefits
- Melanocortin System Research — Melanotan II (MT-II) is a non-selective melanocortin receptor agonist (MC1R-MC5R), making it a versatile tool for studying the full melanocortin system.
- Melanogenesis Studies — MT-II induces eumelanin production via MC1R activation, enabling research into UV photoprotection and pigmentation biology.
- Appetite Regulation — MC4R agonism by MT-II reduces food intake in animal models, supporting research into melanocortin-mediated energy homeostasis.
- Behavioral Neuroscience — MT-II's effects on multiple MCRs provide a broad-spectrum tool for studying melanocortin involvement in social behavior, arousal, and stress responses.
Mechanism of Action
Melanotan II is a synthetic cyclic heptapeptide analog of α-MSH. It is a non-selective agonist at melanocortin receptors MC1R through MC5R.
MC1R (Melanogenesis): Activation stimulates adenylyl cyclase, increasing cAMP and activating MITF transcription factor, which upregulates tyrosinase and melanin synthesis in melanocytes.
MC3R/MC4R (Behavioral/Metabolic): Central agonism reduces appetite (MC4R), modulates sexual behavior (MC3R/MC4R), and influences stress responses through hypothalamic signaling.
MC5R (Exocrine): Activation modulates exocrine gland secretion, including sebaceous gland activity.
Cyclic Structure: The lactam bridge between residues confers proteolytic resistance and enhanced receptor binding affinity compared to linear α-MSH.
Research Protocol
Derived from published research. For research use only.
Reconstitution
Reconstitute in bacteriostatic water. Stock: 1-2 mg/mL.
Research Dosing (from published studies)
- In vivo (murine, melanogenesis): 0.5-1.0 mg/kg SC daily for 7-14 days.
- In vivo (feeding studies): 1-10 nmol ICV for acute anorectic response.
- In vitro: 10 nM - 10 μM for melanocyte stimulation and cAMP assays.
Storage
Lyophilized at -20°C. Reconstituted at 2-8°C, use within 21 days.
Safety & Handling
Research Use Only.
Storage Conditions
- Lyophilized: -20°C, protected from light
- Reconstituted: 2-8°C, 21 days
Known Considerations from Literature
- MT-II's non-selective receptor profile produces multiple concurrent effects (pigmentation, appetite suppression, behavioral changes) that complicate single-pathway studies.
- Nausea and facial flushing are commonly reported in research settings at higher doses.
- Potential for melanocyte activation warrants monitoring for atypical pigmentation in chronic studies.
- MC4R agonism may affect cardiovascular parameters (blood pressure, heart rate).
Handling
Standard PPE. Protect from light during handling and storage.
Frequently Asked Questions
- What is Melanotan II?
- Melanotan II is a synthetic cyclic heptapeptide that acts as a non-selective agonist at all five melanocortin receptors (MC1R-MC5R). It was originally developed for melanogenesis and photoprotection research.
- How does MT-II differ from MT-I?
- MT-I (Afamelanotide) is a linear peptide that is relatively selective for MC1R (melanogenesis). MT-II is a cyclic peptide with activity across all MCRs, producing broader effects including appetite, behavioral, and pigmentation changes.
- Why is MT-II light-sensitive?
- The peptide contains aromatic amino acid residues susceptible to photo-oxidation. Store protected from light and reconstitute in amber vials when possible.
- What purity is this product?
- BeaCapra Melanotan II is ≥99% pure by HPLC with full COA.
Related formulas
Customer Reviews
Exceptional purity and fast shipping
Third-party COA verified at 99.1% purity. Arrived in 2 days with proper cold packaging. The documentation included was thorough and professional. Will be ordering again for our lab.
Best supplier I've found
After trying several suppliers, BeaCapra consistently delivers the highest quality compounds. The subscribe & save option is a great value, and their customer support team answered all my questions promptly.
Great product, COA checks out
Ran our own HPLC analysis and confirmed the purity claims. Packaging was secure and discreet. Only minor note — would love to see more size options for some of the newer compounds. Otherwise excellent.
Subscribe & save is the way to go
The 15% discount on subscription makes this the most competitive pricing I've found for research-grade compounds at this purity level. Auto-delivery every 30 days has been seamless. Highly recommend.
Exactly what our research team needed
We've been sourcing from BeaCapra for our university lab and the consistency batch-to-batch is impressive. Every order comes with a COA and the compounds are properly lyophilized. Professional operation all around.
Questions About MT-2 Melanotan II
General Questions
Everything you need to know about BeaCapra research peptides, ordering, shipping, and our commitment to quality.
Still have questions? Our research specialists are here to help.
Contact Us