Selank
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Selank by BeaCapra — premium research-grade compound verified to ≥99.0% purity via independent HPLC and LC-MS analysis.
Supplied as lyophilized (freeze-dried) powder in vacuum-sealed glass vials. Each batch undergoes rigorous third-party testing to ensure pharmaceutical-grade consistency and stability.
Specifications
- Purity: ≥99.0% (HPLC verified)
- Form: Lyophilized Powder
- Category: Cognitive Function
- Storage: -20°C recommended, protect from light
Quality Assurance
Every BeaCapra product ships with a Certificate of Analysis (COA) documenting purity verification via HPLC and mass spectrometry. Our compounds are synthesized under strict GMP-adjacent protocols and undergo batch-level quality control.
For Research Use Only (RUO). Not intended for human consumption, therapeutic, or diagnostic use.
Research-Documented Benefits
- Anxiolytic Effects — Selank, a tuftsin analog, demonstrates anxiolytic activity comparable to benzodiazepines in preclinical models without sedation or dependence potential.
- Immune Enhancement — Research shows modulation of IL-6 and interferons, supporting both innate and adaptive immune responses.
- Cognitive Support — Studies document improved memory trace stability and enhanced information processing, particularly under stress conditions.
- Enkephalinase Inhibition — Selank inhibits enkephalin-degrading enzymes, prolonging the activity of endogenous opioid peptides involved in mood regulation.
- Antiviral Properties — Preclinical research suggests enhanced antiviral defense through induction of interferon and modulation of immune cell activity.
Mechanism of Action
Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro) is a synthetic heptapeptide analog of the naturally occurring immunomodulatory peptide tuftsin (Thr-Lys-Pro-Arg), with a C-terminal Pro-Gly-Pro extension for improved stability.
Primary Pathways
- GABAergic Modulation — Selank enhances GABA-mediated inhibitory neurotransmission, producing anxiolytic effects without the sedation, tolerance, or dependence associated with benzodiazepine receptor agonists.
- Enkephalin Stabilization — Inhibits enkephalinase enzymes that degrade endogenous enkephalins, prolonging the activity of these natural anxiolytic peptides.
- Cytokine Modulation — Regulates balance between pro-inflammatory (IL-6) and anti-inflammatory cytokines, contributing to both anxiolytic and immunomodulatory effects.
- Monoamine Metabolism — Influences metabolism of serotonin and norepinephrine, modulating emotional processing and stress response circuits.
Selank's dual anxiolytic-immunomodulatory mechanism is derived from its tuftsin backbone (immune) combined with the stabilizing Pro-Gly-Pro extension that enables CNS activity (anxiolytic).
Research Protocol Guidelines
All protocols described are for in vitro and in vivo research purposes only. Not for human use.
Preparation
Selank is most commonly supplied as a 0.15% nasal spray solution. Lyophilized powder may also be available for custom formulation research.
Research Dosing (Published Literature)
- Standard research dose: 250-500 mcg/day intranasally, divided into 2-3 administrations
- Anxiolytic studies: 250-750 mcg/day for 14-day treatment periods in clinical research
- Immune modulation: 200 mcg/day in immunological research protocols lasting 10-14 days
- In vivo (rodent): 100-300 mcg/kg intranasally in anxiety and immune function models
Storage
Store nasal spray at 2-8°C. Lyophilized form at -20°C. Reconstituted solutions at 2-8°C, use within 14 days.
Safety & Handling Information
For research use only. Not intended for human or veterinary diagnostic or therapeutic use.
Storage Requirements
- Nasal spray: 2-8°C, use within 14 days
- Lyophilized: -20°C for long-term storage
Clinical Safety Data
Selank is approved in Russia as an anxiolytic and nootropic, with a clinical safety record supporting good tolerability. No sedation, cognitive impairment, or dependence potential has been reported.
Known Considerations
- GABAergic modulation is fundamentally different from benzodiazepine receptor agonism—no cross-tolerance or additive sedation expected with GABA-A modulators
- Immune modulation (cytokine effects) may confound immunological research endpoints
- No anticholinergic, antihistaminergic, or adrenolytic activity at standard doses
- Well-tolerated in combination with semax in published research protocols
Handling
Standard laboratory PPE. Similar handling requirements to semax.
Frequently Asked Questions
How does selank compare to benzodiazepines in research?
Selank demonstrates anxiolytic activity comparable to diazepam in animal behavioral models (elevated plus maze, light-dark box) without producing sedation, muscle relaxation, amnesia, or dependence. Its mechanism (GABA modulation + enkephalinase inhibition) is fundamentally different from benzodiazepine GABA-A receptor allosteric modulation.
What is tuftsin and why does it matter?
Tuftsin (Thr-Lys-Pro-Arg) is a naturally occurring tetrapeptide derived from the Fc domain of IgG. It stimulates phagocytosis and natural killer cell activity. Selank retains tuftsin's immunomodulatory backbone while the Pro-Gly-Pro extension adds CNS penetration and anxiolytic properties.
Does selank affect immune function?
Yes. Selank modulates both innate and adaptive immunity through its tuftsin backbone. Published research shows effects on IL-6 levels, interferon production, and T-cell activity. This dual anxiolytic-immunomodulatory profile is unique among research peptides.
Is selank approved anywhere?
Selank is approved in Russia as an anxiolytic and nootropic medication. It does not have FDA approval in the United States or EMA approval in the European Union. In most jurisdictions outside Russia, it is available as a research compound only.
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Customer Reviews
Exceptional purity and fast shipping
Third-party COA verified at 99.1% purity. Arrived in 2 days with proper cold packaging. The documentation included was thorough and professional. Will be ordering again for our lab.
Best supplier I've found
After trying several suppliers, BeaCapra consistently delivers the highest quality compounds. The subscribe & save option is a great value, and their customer support team answered all my questions promptly.
Great product, COA checks out
Ran our own HPLC analysis and confirmed the purity claims. Packaging was secure and discreet. Only minor note — would love to see more size options for some of the newer compounds. Otherwise excellent.
Subscribe & save is the way to go
The 15% discount on subscription makes this the most competitive pricing I've found for research-grade compounds at this purity level. Auto-delivery every 30 days has been seamless. Highly recommend.
Exactly what our research team needed
We've been sourcing from BeaCapra for our university lab and the consistency batch-to-batch is impressive. Every order comes with a COA and the compounds are properly lyophilized. Professional operation all around.
Questions About Selank
General Questions
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