TB-500
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TB-500 by BeaCapra — premium research-grade compound verified to ≥99.0% purity via independent HPLC and LC-MS analysis.
Supplied as lyophilized (freeze-dried) powder in vacuum-sealed glass vials. Each batch undergoes rigorous third-party testing to ensure pharmaceutical-grade consistency and stability.
Specifications
- Purity: ≥99.0% (HPLC verified)
- Form: Lyophilized Powder
- Category: Recovery Research
- Storage: -20°C recommended, protect from light
Quality Assurance
Every BeaCapra product ships with a Certificate of Analysis (COA) documenting purity verification via HPLC and mass spectrometry. Our compounds are synthesized under strict GMP-adjacent protocols and undergo batch-level quality control.
For Research Use Only (RUO). Not intended for human consumption, therapeutic, or diagnostic use.
Research-Documented Benefits
- Wound Healing Acceleration — Thymosin Beta-4 has demonstrated significant enhancement of wound closure rates, promoting both dermal and cardiac tissue repair in preclinical studies.
- Anti-Inflammatory Effects — Research shows downregulation of pro-inflammatory cytokines and chemokines, reducing tissue swelling and secondary damage following injury.
- Cardiac Repair — Studies in murine models demonstrate improved cardiac function post-myocardial infarction, with enhanced cardiomyocyte survival and reduced fibrosis.
- Cell Migration & Differentiation — Promotes migration of endothelial cells, keratinocytes, and stem cells to sites of tissue damage, supporting the body's natural repair cascades.
- Hair Follicle Stem Cell Activation — Research indicates stimulation of hair follicle stem cell migration and differentiation, with improved hair growth observed in animal models.
Mechanism of Action
TB-500 is the active region (amino acids 17-23) of Thymosin Beta-4, a 43-amino acid peptide that is the primary G-actin sequestering molecule in mammalian cells.
Primary Pathways
- Actin Sequestration — Binds monomeric G-actin, regulating actin polymerization dynamics. This controls cell motility, shape, and the cytoskeletal rearrangements required for migration through tissue.
- Cell Migration Promotion — By modulating the actin cytoskeleton, TB-500 promotes migration of endothelial cells, keratinocytes, and progenitor cells toward sites of injury.
- Anti-Inflammatory Signaling — Downregulates NF-kB-mediated inflammatory cascades, reducing production of pro-inflammatory cytokines (TNF-alpha, IL-1beta, IL-6).
- MMP Regulation — Modulates matrix metalloproteinase expression, balancing extracellular matrix degradation and deposition during tissue remodeling.
TB-500's central role in actin dynamics positions it at a convergence point of multiple repair pathways, including angiogenesis, re-epithelialization, and stem cell recruitment.
Research Protocol Guidelines
All protocols described are for in vitro and in vivo research purposes only. Not for human use.
Reconstitution
Reconstitute lyophilized TB-500 with bacteriostatic water. For a 5 mg vial, adding 2 mL yields 2.5 mg/mL. Swirl gently until dissolved; peptide typically dissolves readily at room temperature.
Research Dosing (Preclinical Literature)
- Loading phase: 2-6 mg administered subcutaneously, twice weekly for 4-6 weeks in equine and canine research models
- Maintenance phase: 2-6 mg administered subcutaneously, once or twice monthly following the loading period
- Rodent studies: 6 mg/kg body weight intraperitoneally or subcutaneously
- Routes studied: Subcutaneous, intraperitoneal, intracardiac (research models only)
Storage
Store lyophilized powder at -20°C. Reconstituted solution at 2-8°C, use within 14-21 days. TB-500 is relatively stable in solution but should be protected from light and temperature extremes.
Safety & Handling Information
For research use only. Not intended for human or veterinary diagnostic or therapeutic use.
Storage Requirements
- Lyophilized: -20°C, desiccated, protected from light
- Reconstituted: 2-8°C, use within 14-21 days
Preclinical Safety Profile
Thymosin Beta-4 is an endogenous peptide present at high concentrations in all mammalian cells. Exogenous supplementation in preclinical models has not demonstrated significant adverse effects at standard research doses.
Known Considerations
- Cell migration and angiogenesis promotion warrants caution in models with pre-existing neoplastic processes; while TB-500 has not been shown to initiate tumors, its pro-migratory effects require consideration
- No reported hepatotoxicity, nephrotoxicity, or immunotoxicity at standard research doses
- Equine and canine veterinary research databases provide additional safety data across larger animal models
Handling
Use standard laboratory PPE. Handle under aseptic conditions. Reconstituted TB-500 may be subject to microbial contamination; use bacteriostatic water and sterile technique.
Frequently Asked Questions
What is TB-500 and how does it relate to Thymosin Beta-4?
TB-500 refers to the active fragment region (amino acids 17-23, sequence LKKTETQ) of the full-length 43-amino acid protein Thymosin Beta-4. This fragment retains the actin-binding and cell migration properties of the parent molecule in a more practical research format.
What distinguishes TB-500 from BPC-157?
While both are studied for tissue repair, they work through entirely different mechanisms. TB-500 modulates actin dynamics and cell migration, while BPC-157 upregulates growth factors and the nitric oxide system. They are often studied in combination for their complementary effects.
Does TB-500 require a loading phase in research protocols?
Most published research protocols include an initial loading phase (higher frequency administration for 4-6 weeks) followed by a reduced maintenance schedule. This protocol design is based on the kinetics of tissue repair cascades observed in equine and canine research.
How quickly does TB-500 degrade after reconstitution?
Reconstituted TB-500 in bacteriostatic water stored at 2-8°C maintains potency for approximately 14-21 days. For longer storage, aliquot into single-use volumes and freeze at -20°C to prevent peptide degradation.
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Customer Reviews
Exceptional purity and fast shipping
Third-party COA verified at 99.1% purity. Arrived in 2 days with proper cold packaging. The documentation included was thorough and professional. Will be ordering again for our lab.
Best supplier I've found
After trying several suppliers, BeaCapra consistently delivers the highest quality compounds. The subscribe & save option is a great value, and their customer support team answered all my questions promptly.
Great product, COA checks out
Ran our own HPLC analysis and confirmed the purity claims. Packaging was secure and discreet. Only minor note — would love to see more size options for some of the newer compounds. Otherwise excellent.
Subscribe & save is the way to go
The 15% discount on subscription makes this the most competitive pricing I've found for research-grade compounds at this purity level. Auto-delivery every 30 days has been seamless. Highly recommend.
Exactly what our research team needed
We've been sourcing from BeaCapra for our university lab and the consistency batch-to-batch is impressive. Every order comes with a COA and the compounds are properly lyophilized. Professional operation all around.
Questions About TB-500
General Questions
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