VIP Spray
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VIP Spray by BeaCapra — premium research-grade compound verified to ≥99.0% purity via independent HPLC and LC-MS analysis.
Supplied as a pre-dissolved metered nasal spray solution in a 30ml amber glass atomizer with precision dosing mechanism. Each actuation delivers a consistent, measured dose for reliable experimental protocols.
Specifications
- Purity: ≥99.0% (HPLC verified)
- Form: Pre-Dissolved Metered Spray (30ml)
- Category: Metabolic Research
- Storage: -20°C recommended, protect from light
Quality Assurance
Every BeaCapra product ships with a Certificate of Analysis (COA) documenting purity verification via HPLC and mass spectrometry. Our compounds are synthesized under strict GMP-adjacent protocols and undergo batch-level quality control.
For Research Use Only (RUO). Not intended for human consumption, therapeutic, or diagnostic use.
Research Benefits
- Neuroprotection — VIP (Vasoactive Intestinal Peptide) is a 28-amino acid neuropeptide with demonstrated neuroprotective effects in models of neuroinflammation, excitotoxicity, and neurodegenerative disease.
- Pulmonary Research — VIP's vasodilatory and anti-inflammatory properties in the pulmonary vasculature make it valuable for pulmonary hypertension and COPD research models.
- Circadian Biology — VIP is a key neurotransmitter in the suprachiasmatic nucleus (SCN), essential for maintaining circadian rhythm synchronization among SCN neurons.
- GI Physiology — As a major enteric neuropeptide, VIP regulates intestinal secretion, motility, and mucosal immunity, supporting gastrointestinal research.
- Anti-Inflammatory — VIP suppresses pro-inflammatory cytokine production and promotes regulatory T-cell differentiation, making it a tool for immunology research.
Mechanism of Action
VIP is a 28-amino acid peptide belonging to the secretin/glucagon superfamily. It signals through two G-protein coupled receptors: VPAC1 and VPAC2.
VPAC1/VPAC2 Signaling: Both receptors couple to Gs, activating adenylyl cyclase and increasing intracellular cAMP. This activates PKA and Epac, mediating VIP's diverse biological effects.
Vasodilation: VIP relaxes vascular smooth muscle through cAMP-dependent inhibition of myosin light chain kinase and direct NO synthase activation in endothelial cells.
Neuroprotection: VIP activates VPAC2 on neurons, upregulating BDNF and activity-dependent neuroprotective protein (ADNP), and inhibiting excitotoxic calcium influx.
Immunomodulation: VIP shifts macrophage polarization from M1 (pro-inflammatory) to M2 (anti-inflammatory), suppresses Th1 responses, and promotes Treg differentiation through VPAC1 signaling on immune cells.
Research Protocol
For research use only.
Reconstitution
Reconstitute in sterile water or PBS with 0.1% BSA carrier. Stock: 100 μg/mL. VIP adsorbs to surfaces; use siliconized or low-binding tubes.
Research Dosing
- In vivo (murine): 1-10 nmol/mouse IP or IV for immunomodulation; ICV for circadian studies.
- In vitro: 1-100 nM for macrophage polarization, T-cell differentiation, and neuronal survival assays.
- Pulmonary models: Nebulized delivery at 100-200 μg/mL in aerosol for pulmonary research.
Storage
Lyophilized at -20°C. Reconstituted: aliquot at -80°C. Working solutions at 2-8°C, use same day.
Safety & Handling
Research Use Only.
Known Considerations
- VIP has a very short plasma half-life (~1 minute) due to rapid enzymatic degradation by DPP-IV and neutral endopeptidase.
- Vasodilatory effects may cause transient hypotension at high systemic doses.
- VIP can stimulate secretory diarrhea at high enteric doses through chloride channel activation.
- Use fresh preparations; VIP is unstable in aqueous solution.
Frequently Asked Questions
- What is VIP?
- Vasoactive Intestinal Peptide is a 28-amino acid neuropeptide widely distributed in the central and peripheral nervous systems. It functions as a neurotransmitter, vasodilator, and immunomodulator.
- Why does VIP need BSA carrier?
- VIP readily adsorbs to plastic and glass surfaces. Adding 0.1% BSA or using low-binding tubes prevents concentration loss during handling and storage.
- What purity is this product?
- BeaCapra VIP is ≥99% pure by HPLC with COA provided.
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Customer Reviews
Exceptional purity and fast shipping
Third-party COA verified at 99.1% purity. Arrived in 2 days with proper cold packaging. The documentation included was thorough and professional. Will be ordering again for our lab.
Best supplier I've found
After trying several suppliers, BeaCapra consistently delivers the highest quality compounds. The subscribe & save option is a great value, and their customer support team answered all my questions promptly.
Great product, COA checks out
Ran our own HPLC analysis and confirmed the purity claims. Packaging was secure and discreet. Only minor note — would love to see more size options for some of the newer compounds. Otherwise excellent.
Subscribe & save is the way to go
The 15% discount on subscription makes this the most competitive pricing I've found for research-grade compounds at this purity level. Auto-delivery every 30 days has been seamless. Highly recommend.
Exactly what our research team needed
We've been sourcing from BeaCapra for our university lab and the consistency batch-to-batch is impressive. Every order comes with a COA and the compounds are properly lyophilized. Professional operation all around.
Questions About VIP Spray
General Questions
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