B12
Frequently Bought Together
B12 by BeaCapra — premium research-grade compound verified to ≥99.0% purity via independent HPLC and LC-MS analysis.
Supplied as lyophilized (freeze-dried) powder in vacuum-sealed glass vials. Each batch undergoes rigorous third-party testing to ensure pharmaceutical-grade consistency and stability.
Specifications
- Purity: ≥99.0% (HPLC verified)
- Form: Lyophilized Powder
- Category: Aminos
- Storage: -20°C recommended, protect from light
Quality Assurance
Every BeaCapra product ships with a Certificate of Analysis (COA) documenting purity verification via HPLC and mass spectrometry. Our compounds are synthesized under strict GMP-adjacent protocols and undergo batch-level quality control.
For Research Use Only (RUO). Not intended for human consumption, therapeutic, or diagnostic use.
Research Benefits
- Methylation Research — Vitamin B12 (cobalamin) is an essential cofactor for methionine synthase, the enzyme that remethylates homocysteine to methionine, supporting the universal methylation cycle.
- Neurological Function — B12 is required for myelin synthesis and maintenance, making it critical for neuroscience research on demyelination and peripheral neuropathy models.
- Hematopoiesis — B12 deficiency causes megaloblastic anemia; B12 supplementation studies support red blood cell maturation and DNA synthesis research.
- One-Carbon Metabolism — B12 links folate metabolism to the methionine cycle, serving as a tool for studying one-carbon transfer reactions.
Mechanism of Action
Vitamin B12 functions as a cofactor for two enzymes in mammals:
Methionine Synthase (MS): Methylcobalamin (MeCbl) transfers a methyl group from 5-methyltetrahydrofolate (5-MTHF) to homocysteine, regenerating methionine and tetrahydrofolate (THF). This reaction connects the folate cycle to the methionine/SAM cycle.
Methylmalonyl-CoA Mutase (MCM): Adenosylcobalamin (AdoCbl) catalyzes the isomerization of methylmalonyl-CoA to succinyl-CoA, a key step in odd-chain fatty acid and branched-chain amino acid catabolism via the TCA cycle.
"Methyl Trap" Hypothesis: B12 deficiency traps folate as 5-MTHF (unable to regenerate THF), causing functional folate deficiency despite adequate folate levels, explaining the megaloblastic anemia of B12 deficiency.
Research Protocol
For research use only.
Preparation
B12 is water-soluble. Stock: 1 mg/mL in sterile water. Protect from light (photolabile).
Storage
Store at 2-8°C, protected from light. Solution stable for months when refrigerated and protected.
Safety & Handling
Research Use Only.
Known Considerations
- B12 is water-soluble with minimal toxicity risk even at high doses; excess is excreted renally.
- Photosensitive — protect from light during storage and handling.
- Cyanocobalamin contains a cyanide moiety released upon metabolism; methylcobalamin avoids this.
Frequently Asked Questions
- What forms of B12 are available?
- Common forms include cyanocobalamin (synthetic, most stable), methylcobalamin (active methyl-donor form), hydroxocobalamin (long-acting), and adenosylcobalamin (mitochondrial cofactor form).
- What purity is this product?
- BeaCapra B12 is pharmaceutical-grade with COA documentation.
Related formulas
Customer Reviews
Exceptional purity and fast shipping
Third-party COA verified at 99.1% purity. Arrived in 2 days with proper cold packaging. The documentation included was thorough and professional. Will be ordering again for our lab.
Best supplier I've found
After trying several suppliers, BeaCapra consistently delivers the highest quality compounds. The subscribe & save option is a great value, and their customer support team answered all my questions promptly.
Great product, COA checks out
Ran our own HPLC analysis and confirmed the purity claims. Packaging was secure and discreet. Only minor note — would love to see more size options for some of the newer compounds. Otherwise excellent.
Subscribe & save is the way to go
The 15% discount on subscription makes this the most competitive pricing I've found for research-grade compounds at this purity level. Auto-delivery every 30 days has been seamless. Highly recommend.
Exactly what our research team needed
We've been sourcing from BeaCapra for our university lab and the consistency batch-to-batch is impressive. Every order comes with a COA and the compounds are properly lyophilized. Professional operation all around.
Questions About B12
General Questions
Everything you need to know about BeaCapra research peptides, ordering, shipping, and our commitment to quality.
Still have questions? Our research specialists are here to help.
Contact Us